Dr. Danny Jans

Current Position

2002 - 2005
Post-doctoral researcher
Laboratory of Physiology
Faculty of Medicine 
Hasselt University
Campus Diepenbeek
Agoralaan - Gebouw D
B3590 Diepenbeek
Belgium


University Education

1997 – 2002: Ph. D student, Laboratory of Physiology, Faculty of Medicine, Katholieke Universiteit Leuven Onderwijs & Navorsing, B-3000 Leuven, Belgium 

September 2001: Ph. D. in Medical Sciences
Thesis: Na+ Reabsorption and Cl- Secretion Across Cultured Renal Epithelia (A6): Effects Of Hypotonicity and External Cations. Acta Biomedica Lovaniensia, No. 245, Leuven University Press. ISBN: 90-5867-173-9

1993 – 1995: Biomedical Sciences, Faculteit van Geneeskunde, Vrije Universiteit Brussel

Teaching

Homeostase: coördinerend assistent - suppleant Prof. Dr. Paul Steels
Receptoren
Fysiologie van de zintuigen
Interactief programmeren voor computerpractica: (1) membraan- en actiepotentiaal; (2) karakteristieken van de binding tussen receptoren en hun liganden; (3) spierfysiologie

Research Project

The search for the mechanisms behind ion transport and the properties of the transporters involved in:

1) renal epithelia: mechanisms of Na+ reabsorption and Cl- secretion by tight epithelia of the distal renal tubule - effects of heavy metals

2) Xenopus laevis oocytes: investigation into the properties of the epithelial Na+ channel (ENaC) and the cAMP-activated Cl- channel CFTR by use of the oocyte expression system


Publications (articles in peer review journals)

Jans D, Simaels J, Larivière E, Steels P and Van Driessche W. Extracellular Ca2+ regulates the stimulation of Na+ transport in A6 renal epithelia. Am J Physiol Renal Physiology 287:FXX (2004)

Cucu D, Simaels J, Jans D, Van Driessche W. The transoocyte voltage clamp: a non-invasive technique for electrophysiological experiments with Xenopus laevis oocytes. Pflügers Arch. 447(6):934-42 (2004)

Srinivas SP, Bonanno JA, Lariviere E, Jans D, Van Driessche W. Measurement of rapid changes in cell volume by forward light scattering. Pflügers Arch. 447(1):97-108 (2003)

Jans D, Srinivas SP, Waelkens E, Segal A, Lariviere E, Simaels J, Van Driessche W. Hypotonic treatment evokes biphasic ATP release across the basolateral membrane of cultured renal epithelia (A6). J Physiol. 545:543-55 (2002)

Jans D, De Weer P, Srinivas SP, Lariviere E, Simaels J, Van Driessche W. Mg2+-sensitive non-capacitative basolateral Ca2+ entry secondary to cell swelling in the polarized renal A6 epithelium. J Physiol. 541:91-101 (2002)

Jans D, Simaels J, Cucu D, Zeiske W, Van Driessche W. Effects of extracellular Mg2+ on transepithelial capacitance and Na+ transport in A6 cells under different osmotic conditions. Pflügers Arch. 439(5):504-12 (2000)

Van Driessche W, De Vos R, Jans D, Simaels J, De Smet P, Raskin G. Transepithelial capacitance decrease reveals closure of lateral interspace in A6 epithelia. Pflügers Arch. 437(5):680-90 (1999)

Li J, De Smet P, Jans D, Simaels J, Van Driessche W. Swelling-activated cation-selective channels in A6 epithelia are permeable to large cations. Am J Physiol. Cell Physiology 275:C358-66 (1998)

Braet F, De Zanger R, Jans D, Spector I, Wisse E. Microfilament-disrupting agent latrunculin A induces and increased number of fenestrae in rat liver sinusoidal endothelial cells: comparison with cytochalasin B. Hepatology 24(3):627-35 (1996)

Wisse E, Braet F, Luo D, De Zanger R, Jans D, Crabbe E, Vermoesen A. Structure and function of sinusoidal lining cells in the liver. Toxicol Pathol. 24(1):100-11 (1996)

Hubrechts JM, Vanhoof R, Eeckelaert A, Jans D, Lessire MN, Van Meeuwen J, Vandenabeele A, Van Waes D, Vuylsteke M, Woestyn J. The "in vitro" susceptibility of urinary tract pathogens to mecillinam, compared with nine other antimicrobial agents. A multicenter study. Acta Urol Belg. 1986;54(3):353-61


Membership Scientific Associations

American Physiological Society
American Society for Biochemistry and Molecular Biology
Belgisch Genootschap voor Fundamentele en Klinische Fysiologie en Pharmacologie